Rat IL-2 Recombinant Rabbit Monoclonal Antibody [PSH05-72] - BSA and Azide free (Detector)

About this product

Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.

Specifications

Catalog number

HA722424

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Aldesleukin antibody IL 2 antibody IL-2 antibody IL2 antibody IL2_HUMAN antibody Interleukin 2 antibody Interleukin-2 antibody interleukin2 antibody Involved in regulation of T cell clonal expansion antibody Lymphokine antibody OTTHUMP00000164090 antibody POIL2 antibody T Cell Growth Factor antibody T-cell growth factor antibody TCGF antibody

Abbreviation

Interleukin-2 IL-2 T-cell growth factor (TCGF) Il2 Il-2

Swiss Prot

P17108 Rat

Host

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant protein within Rat IL-2 aa 21-155.

Isotype

IgG

Clone

PSH05-72

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant standard Rat IL-2 protein (HA210683).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH05-71] to Rat IL-2 (Capture) (HA722423) and recombinant standard Rat IL-2 protein (HA210683) as the standard. The reference range value is 30.9-2500 pg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Molecular Weight

Predicted band size: 17.6 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes