Homer2 Rabbit Polyclonal Antibody

Catalog number HA500538

Price for HA500538

Size / count 100 µL

About this product

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

Specifications

Catalog number: HA500538
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Homer protein homolog 2 Homer-2 Cupidin HOMER2
Abbreviation: HOMER2
Swiss Prot: Q9NSB8 Human
Cellular Locus: Cell membrane, cytoplasm, postsynaptic density, synapse, stereocilium.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human Homer2 aa 284-333 / 354.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: HepG2 cell lysate, LO2 cell lysate, Huh7 cell lysate, A549 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 41 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Homer2 Rabbit Polyclonal Antibody?

The catalog number for Homer2 Rabbit Polyclonal Antibody is HA500538.

What sizes are available for Homer2 Rabbit Polyclonal Antibody?

Homer2 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Homer2 Rabbit Polyclonal Antibody in stock?

Homer2 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Homer2 Rabbit Polyclonal Antibody used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.