HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52]

Catalog number HA722998

Price for HA722998

Size / count 100 µL

About this product

In biochemistry, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is overactivated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis. In humans, the protein is encoded by the HMGCS1 gene on chromosome 5.

Specifications

Catalog number: HA722998
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) antibody 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody cytoplasmic antibody EC 2.3.3.10 antibody HMCS1_HUMAN antibody HMG CoA synthase antibody HMG-CoA synthase antibody HMGCS antibody HMGCS1 antibody Hydroxymethylglutaryl CoA synthase, cytoplasmic antibody Hydroxymethylglutaryl-CoA synthase antibody MGC90332 antibody
Abbreviation: Hydroxymethylglutaryl-CoA synthase, cytoplasmic, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS1, HMGCS
Swiss Prot: Q01581 Human, Q8JZK9 Mouse, P17425 Rat
Cellular Locus: Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human HMGCS1 aa 421-520.
Isotype: IgG
Clone: PSH08-52
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IF-Tissue, IP
Positive Control: HepG2 cell lysate, MCF7 cell lysate, HT-29 cell lysate, A549 cell lysate, U-2 OS cell lysate, human liver tissue, mouse liver tissue, rat liver tissue, human lung cancer tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:200-1:1,000 ;IF-Tissue: 1:200 ;IP: 1-2μg/sample
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 57 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52]?

The catalog number for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] is HA722998.

What sizes are available for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52]?

HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] is available in the following size(s): 100 µL.

Is HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] in stock?

HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] is currently made to order / not held in immediate stock. Contact us for lead time.

What is HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] used for?

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.