Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector)

Catalog number HA721837

Price for HA721837

Size / count 100 µL

About this product

Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.

Specifications

Catalog number: HA721837
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Catabolin antibody H1 antibody IFN beta inducing factor antibody IL 1 antibody IL 1 beta antibody IL-1 beta antibody IL1 antibody IL1 BETA antibody IL1B antibody IL1B_HUMAN antibody IL1F2 antibody Interleukin 1 beta antibody Interleukin 1 beta precursor antibody interleukin 1, beta antibody Interleukin-1 beta antibody OAF antibody Osteoclast activating factor antibody OTTHUMP00000162031 antibody Preinterleukin 1 beta antibody Preinterleukin beta antibody Pro interleukin 1 beta antibody
Abbreviation: Interleukin-1 beta IL-1 beta Il1b
Swiss Prot: Q63264 Rat
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Rat
Immunogen: Recombinant protein within Rat IL-1 beta aa 117-268 (Q63264).
Isotype: IgG
Clone: PSH02-60
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Det)
Positive Control: Recombinant Rat il-1 beta protein (HA210708).
Concentration: 1 mg/mL
Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH02-59] to Rat IL-1 beta (Capture) (HA721836) and recombinant standard Rat IL-1 beta (HA210708) as the standard. The reference range value is 30.9-2500pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 30.6 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector)?

The catalog number for Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector) is HA721837.

What sizes are available for Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector)?

Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector) is available in the following size(s): 100 µL.

Is Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector) in stock?

Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PSH02-60] - BSA and Azide free (Detector) used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.