Activin A Receptor Type IB Recombinant Rabbit Monoclonal Antibody [JE38-48]

About this product

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Specifications

Catalog number

HA721550

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Activin A receptor type 1B Activin A receptor type II like kinase 4 Activin A type 1B receptor Activin A type IB receptor Activin receptor like kinase 4 Activin receptor type 1B Activin receptor type IB Activin receptor type-1B Activin receptor-like kinase 4 ACTR IB ACTR-IB ACTRIB ACV1B_HUMAN ACVR 1B Acvr1b ACVRLK 4 ACVRLK4 ALK 4 ALK-4 ALK4 Serine (threonine) protein kinase receptor R2 Serine/threonine-protein kinase receptor R2 SKR 2 SKR2

Abbreviation

ACVR1B

Swiss Prot

P36896 Human, Q61271 Mouse, P80202 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human Activin receptor type-1B aa 24-126.

Isotype

IgG

Clone

JE38-48

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

293T cell lysate, U-87 MG cell lysate, mouse brain tissue lysate, rat brain tissue lysate, rat brain tissue, mouse brain tissue, U-87 MG.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:5,000 ;IF-Cell: 1:250 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 57 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes