p-p21 Antibody (pT145)

Catalog number F48424-0.4ML

Discontinued

Price for F48424-0.4ML

Size / count 0.4 mL

This variant is discontinued and cannot be added to your cart.

About this product

P21CIP1 is a potent cyclin-dependent kinase inhibitor. This protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. Expression is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. P21CIP1 can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein has been reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.

Specifications

Catalog number: F48424-0.4ML
Size / count: 0.4 mL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9007-83-4
UniProt: P38936
Host: Rabbit
Immunogen: This p-p21 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT145 of human P21CIP1.
Clonality: Polyclonal
Isotype: Ig
Applications: WB, DB, IHC, ELISA
Format: Antigen affinity purified
Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution: Aliquot the p-p21 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations: This p-p21 antibody is available for research use only.

Frequently Asked Questions

What is the catalog number for p-p21 Antibody (pT145)?

The catalog number for p-p21 Antibody (pT145) is F48424-0.4ML.

Is p-p21 Antibody (pT145) in stock?

p-p21 Antibody (pT145) is currently made to order / not held in immediate stock. Contact us for lead time.

What is p-p21 Antibody (pT145) used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

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