Phospho-IKK beta Antibody (pS705)

Catalog number F48708-0.4ML

Discontinued

Price for F48708-0.4ML

Size / count 0.4 mL

This variant is discontinued and cannot be added to your cart.

About this product

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Specifications

Catalog number: F48708-0.4ML
Size / count: 0.4 mL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9007-83-4
UniProt: O14920
Host: Rabbit
Immunogen: This phospho-IKK beta antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS705 of human IKKB.
Clonality: Polyclonal
Isotype: Ig
Applications: DB, ELISA
Format: Antigen affinity purified
Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution: Aliquot the phospho-IKK beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations: This phospho-IKK beta antibody is available for research use only.

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