Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06]

Catalog number HA721762

Price for HA721762

Size / count 100 µL

About this product

Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation. Tuberin is phosphorylated on Ser939 and Thr1462 in response to PI3K activation and that the human TSC complex is a direct biochemical target of the PI3K/Akt pathway. This data complements Drosophila genetics studies suggesting the possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway.

Specifications

Catalog number: HA721762
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ43106 antibody LAM antibody OTTHUMP00000158940 antibody OTTHUMP00000198394 antibody OTTHUMP00000198395 antibody PPP1R160 antibody Protein phosphatase 1, regulatory subunit 160 antibody TSC complex subunit 2 antibody tsc2 antibody TSC2_HUMAN antibody TSC4 antibody TSC4 gene, formerly antibody TSC4, formerly antibody Tuberin antibody Tuberous sclerosis 2 antibody Tuberous sclerosis 2 protein antibody Tuberous sclerosis 2 protein homolog antibody
Abbreviation: TSC2, TSC4
Swiss Prot: P49815 Human, Q61037 Mouse
Cellular Locus: Cytoplasm, Membrane.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic phosphopeptide corresponding to residues around Ser939 of human tuberin.
Isotype: IgG
Clone: JE54-06
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: SH-SY5Y treated with 200nM Calyculin A and 1μM Okadaic Acid for 1 hour cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 201 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06]?

The catalog number for Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06] is HA721762.

What sizes are available for Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06]?

Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06] is available in the following size(s): 100 µL.

Is Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06] in stock?

Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-Tuberin (S939) Recombinant Rabbit Monoclonal Antibody [JE54-06] used for?

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.