Prohibitin Antibody

About this product

Prohibitin, also known as PHB1, is a protein that in humans is encoded by the PHB gene. White et al.(1991) mapped the gene to chromosome 17 by analysis of human-mouse somatic cell hybrid cell lines using a genomic fragment of human prohibitin DNA isolated from a library using the rat prohibitin cDNA clone. By in situ hybridization, they localized the gene to 17q21. Sato et al.(1992) isolated the human homolog of the rat gene and mapped it to 17q12-q21 by in situ hybridization. Proliferation of tumor cells depends on new blood vessel formation (angiogenesis) that accompanies malignant progression. Anti-cancer therapies using angiogenesis inhibitors or cytotoxic agents targeted to the vasculature of tumors have been evaluated in clinical trials. Although white fat is a nonmalignant tissue, it has the capability to quickly proliferate and expand. Furthermore, it is highly vascularized. Rupnick et al.(2002) showed that nonspecific angiogenesis inhibitors can prevent the development of obesity of mice.

Specifications

Catalog number

R31032

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

UniProt

P35232

Host

Rabbit

Immunogen

An amino acid sequence from the C-terminus of human PHB1 (KLEAAEDIAYQLSRSRN) was used as the immunogen for this Prohibitin antibody (100% homologous in human, mouse and rat).

Clonality

Polyclonal

Isotype

IgG

Applications

WB, IHC-P, ICC

Format

Antigen affinity purified

Buffer

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Reconstitution

After reconstitution, the Prohibitin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This Prohibitin antibody is available for research use only.