Mitofusin 1 Antibody / MFN1

About this product

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80-90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN�2, and to undergo ubiquitination by MARCH5. MFN�1 has two key domains. One is a coiled�coil region that mediates MFN�1: MFN�1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.

Specifications

Catalog number

RQ6027

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

UniProt

Q8IWA4

Host

Mouse

Immunogen

Amino acids DQLLEFVTEGSHFVEATYKNPELDRIA from the human protein were used as the immunogen for the Mitofusin 1 antibody.

Clonality

Monoclonal

Isotype

IgG2b

Applications

WB, IF

Format

Purified

Buffer

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Reconstitution

After reconstitution, the Mitofusin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This Mitofusin 1 antibody is available for research use only.