MMP3 Recombinant Antibody / Matrix Metalloproteinase 3

About this product

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP3, MMP10 and MMP11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP3 activation of procollagenase can occur via two pathways. Direct activation by MMP3 is slow and activation by MMP3 in conjunction with tissue or plasma proteinases is rapid. MMP10 is expressed in small intestine, and at lower levels in lung and heart. MMP11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Specifications

Catalog number

V3641IHC-7ML

Size / count

7 mL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

UniProt

P08254

Host

Rabbit

Immunogen

Amino acids 317-327 were used as the immunogen for the recombinant MMP3 antibody.

Clonality

Monoclonal

Isotype

IgG κ

Type

Recombinant

Applications

IHC-P

Format

Purified

Buffer

Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Reconstitution

Store the recombinant MMP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This recombinant MMP3 antibody is available for research use only.