SOD1 Antibody / Superoxide Dismutase 1

About this product

Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Specifications

Catalog number

V3869-20UG

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

UniProt

P00441

Host

Mouse

Immunogen

Full length recombinant human protein was used as the immunogen for the SOD1 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Applications

ELISA

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the SOD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This SOD1 antibody is available for research use only.