IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31]

Catalog number HA722819

Price for HA722819

Size / count 100 µL

About this product

Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity).

Specifications

Catalog number: HA722819
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: ACOD1 antibody Aconitate decarboxylase 1 antibody Aconitate decarboxylase antibody CAD antibody Cis aconitate decarboxylase antibody Immune responsive gene 1 protein homolog antibody Immune-responsive gene 1 protein homolog antibody Immunoresponsive 1 homolog (mouse) antibody Irg1 antibody IRG1_HUMAN antibody OC116 antibody OPTB1 antibody TCTIRC7 antibody
Abbreviation: Acod1, Irg1
Swiss Prot: P54987 Mouse
Cellular Locus: Mitochondrion.
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant protein within mouse IRG1 aa 1-488.
Isotype: IgG
Clone: PSH07-31
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: RAW264.7 treated with 0.1μg/mL LPS for 6 hours cell lysate, J774A.1 treated with 1μg/mL LPS for 24 hours cell lysate, mBMMC treated with 0.1μg/mL LPS and 10ng/mL IFN-gamma for 24 hours cell lysate, mBMSC treated with 40ng/mL MCSF for 7 days then add 100ng/mL LPS for 48 hours cell lysate, RAW264.7 cells treated with 0.1μg/mL LPS for 6 hours.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 54 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31]?

The catalog number for IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31] is HA722819.

What sizes are available for IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31]?

IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31] is available in the following size(s): 100 µL.

Is IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31] in stock?

IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31] is currently made to order / not held in immediate stock. Contact us for lead time.

What is IRG1 Recombinant Rabbit Monoclonal Antibody [PSH07-31] used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.