HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51]

Catalog number HA722997

Price for HA722997

Size / count 100 µL

About this product

In biochemistry, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is overactivated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis. In humans, the protein is encoded by the HMGCS1 gene on chromosome 5.

Specifications

Catalog number: HA722997
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) antibody 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody cytoplasmic antibody EC 2.3.3.10 antibody HMCS1_HUMAN antibody HMG CoA synthase antibody HMG-CoA synthase antibody HMGCS antibody HMGCS1 antibody Hydroxymethylglutaryl CoA synthase, cytoplasmic antibody Hydroxymethylglutaryl-CoA synthase antibody MGC90332 antibody
Abbreviation: Hydroxymethylglutaryl-CoA synthase, cytoplasmic, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS1, HMGCS
Swiss Prot: Q01581 Human, Q8JZK9 Mouse, P17425 Rat
Cellular Locus: Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat, Monkey
Immunogen: Recombinant protein within human HMGCS1 aa 421-520.
Isotype: IgG
Clone: PSH08-51
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IP
Positive Control: HepG2 cell lysate, MCF7 cell lysate, HT-29 cell lysate, A549 cell lysate, COS-1 cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, PC-12 cell lysate, Rat liver tissue lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 57 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51]?

The catalog number for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51] is HA722997.

What sizes are available for HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51]?

HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51] is available in the following size(s): 100 µL.

Is HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51] in stock?

HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51] is currently made to order / not held in immediate stock. Contact us for lead time.

What is HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-51] used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.