SLC39A8 Mouse Monoclonal Antibody [A9G3]

About this product

Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity. Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion. Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient. Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic. May also transport iron and cobalt through membranes. Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development. Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization. Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes. Protects, for instance, cells from injury and death at the onset of inflammation. By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries. Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient.

Specifications

Catalog number

HA601161

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

4933419D20Rik antibody AA986696 antibody BCG induced integral membrane protein 103 antibody BCG induced integral membrane protein BIGMo-103 (Up-regulated by BCG-CWS) (Hypothetical protein) antibody LIV-1 subfamily of ZIP zinc transporter 6 antibody LZT Hs6 antibody MGC108852 antibody PP3105 antibody SLC39A8 antibody Solute carrier family 39 (zinc transporter), member 8 antibody Solute carrier family 39 (zinc transporter), member 8 (SLC39A8) antibody Solute carrier family 39 member 8 antibody zinc transporter ZIP8 antibody ZIP8 antibody Zrt- and Irt-like protein 8 antibody

Abbreviation

Metal cation symporter ZIP8 BCG-induced integral membrane protein in monocyte clone 103 protein LIV-1 subfamily of ZIP zinc transporter 6 (LZT-Hs6) Solute carrier family 39 member 8 Zrt- and Irt-like protein 8

Swiss Prot

Q9C0K1 Human, Q91W10 Mouse, Q5FVQ0 Rat

Cellular Locus

Cell membrane.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human SLC39A8 aa 23-132 (Extracellular).

Isotype

IgM

Clone

A9G3

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB

Positive Control

Jurkat cell lysate, SiHa cell lysate, HeLa cell lysate, HUVEC cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 49.6 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No