PD-L2 Mouse Monoclonal Antibody [A10D8]

Catalog number HA601331

Price for HA601331

Size / count 100 µL

About this product

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-L2 binds to its receptor PD-1 with dissociation constant Kd of 11.3 nM. Binding to PD-1 can activate pathways inhibiting TCR/BCR-mediated immune cell activation (for a more detailed discussion see PD-1 signaling). PD-L2 plays an important role in immune tolerance and autoimmunity. Both PD-L1 and PD-L2 can inhibit T cell proliferation and inflammatory cytokine production. Blocking PD-L2 has been shown to exacerbate experimental autoimmune encephalomyelitis. Unlike PD-L1, PD-L2 has been shown activate the immune system. PD-L2 triggers IL-12 production in murine dendritic cells leading to T cell activation. Others have shown that treatment with PD-L2 Ig led to T helper cell proliferation.

Specifications

Catalog number: HA601331
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: B7 dendritic cell molecule antibody B7-DC antibody B7DC antibody bA574F11.2 antibody Btdc antibody Butyrophilin B7 DC antibody Butyrophilin B7-DC antibody Butyrophilin B7DC antibody CD 273 antibody CD273 antibody CD273 antigen antibody MGC142238 antibody MGC142240 antibody PD 1 ligand 2 antibody PD L2 antibody PD-1 ligand 2 antibody PD-L2 antibody PD1 ligand 2 antibody PD1L2_HUMAN antibody PDCD 1 ligand 2 antibody PDCD1 ligand 2 antibody PDCD1L2 antibody Pdcd1lg2 antibody PDL 2 antibody PDL2 antibody Programmed cell death 1 ligand 2 antibody Programmed death ligand 2 antibody
Abbreviation: PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Swiss Prot: Q9BQ51 Human
Cellular Locus: Secreted; Endomembrane system; Cell membrane.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human PD-L2 aa 1-220 / 273.
Isotype: IgG2b
Clone: A10D8
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: Saos-2 cell lysate, MG-63 cell lysate, HDLM-2.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 31 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for PD-L2 Mouse Monoclonal Antibody [A10D8]?

The catalog number for PD-L2 Mouse Monoclonal Antibody [A10D8] is HA601331.

What sizes are available for PD-L2 Mouse Monoclonal Antibody [A10D8]?

PD-L2 Mouse Monoclonal Antibody [A10D8] is available in the following size(s): 100 µL.

Is PD-L2 Mouse Monoclonal Antibody [A10D8] in stock?

PD-L2 Mouse Monoclonal Antibody [A10D8] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PD-L2 Mouse Monoclonal Antibody [A10D8] used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.