Biotin Conjugated Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - Detector

About this product

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.

Specifications

Catalog number

HA723097B

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CTL tryptase antibody CTLA3 antibody Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody Cytotoxic T lymphocyte associated serine esterase 3 antibody Cytotoxic T lymphocyte proteinase 1 antibody Cytotoxic T-lymphocyte proteinase 1 antibody Fragmentin 1 antibody Fragmentin-1 antibody GRAA_HUMAN antibody Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease) antibody Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody Granzyme A antibody Granzyme A precursor antibody Granzyme-1 antibody GZMA antibody H factor antibody Hanukah factor serine protease antibody Hanukkah factor antibody HF antibody HFSP antibody TSP1 antibody

Abbreviation

Granzyme A CTL tryptase Cytotoxic T-lymphocyte proteinase 1 Fragmentin-1 Granzyme-1 Hanukkah factor GZMA CTLA3, HFSP

Swiss Prot

P12544 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Granzyme A aa 29-262.

Isotype

IgG

Clone

PSH09-37

Conjugation

Biotin-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det), ELISA

Positive Control

Recombinant Human Granzyme A protein (HA210916).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH09-36] to Human Granzyme A antibody (Capture) (HA723095) and Recombinant Human Granzyme A protein (HA210916) as the standard. The reference range value is 15.6-2,000 pg/ml. ;ELISA: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes