PF4 Recombinant Rabbit Monoclonal Antibody [JE31-48]

About this product

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan. The gene for human PF4 is located on human chromosome 4. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3-B.

Specifications

Catalog number

HA721584

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C-X-C motif chemokine 4 antibody Chemokine (C X C motif) ligand 4 antibody Chemokine (CXC motif) ligand 4 antibody chemokine ligand 4 antibody CXCL 4 antibody CXCL4 antibody Iroplact antibody MGC138298 antibody Oncostatin A antibody Oncostatin-A antibody OncostatinA antibody PF 4 antibody PF-4 antibody PF4 antibody Pf4a antibody Platelet factor 4 antibody PLF4_HUMAN antibody SCYB 4 antibody SCYB4 antibody short form antibody Small inducible cytokine subfamily B antibody Small inducible cytokine subfamily member 4 antibody

Abbreviation

PF4, CXCL4, SCYB4

Swiss Prot

P02776 Human, P06765 Rat

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within Human PF4 aa 52-101 / 101.

Isotype

IgG

Clone

JE31-48

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Rat spinal cord tissue lysates, human bone marrow tissue, human liver tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 11 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes