SAP97 Recombinant Rabbit Monoclonal Antibody [JE39-74]

About this product

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene. SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1). SAP97 is expressed throughout the body in epithelial cells. In the brain it is involved in the trafficking of ionotropic receptors from the endoplasmic reticulum to the plasma membrane, and may be involved in the trafficking AMPAR during synaptic plasticity. SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane. SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function. Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.

Specifications

Catalog number

HA721502

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Discs large homolog 1 antibody discs large, Drosophila, homolog of, 1 antibody discs, large homolog 1 (Drosophila) antibody Disks large homolog 1 antibody dJ1061C18.1.1 antibody DKFZp761P0818 antibody DKFZp781B0426 antibody DLG 1 antibody DLG1 antibody DLG1_HUMAN antibody DLGH 1 antibody DLGH1 antibody hDlg antibody Presynaptic protein SAP97 antibody SAP 97 antibody SAP-97 antibody SAP97 antibody Synapse associated protein 97 antibody Synapse-associated protein 97 antibody

Abbreviation

DLG1

Swiss Prot

Q12959 Human, Q811D0 Mouse, Q62696 Rat

Cellular Locus

Membrane, Basolateral cell membrane, Endoplasmic reticulum membrane, Postsynaptic density, Synapse, Cell membrane, sarcolemma, Apical cell membrane, Cell junction, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N terminal Human SAP97.

Isotype

IgG

Clone

JE39-74

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

MCF7 cell lysate, HepG2 cell lysate, U-87 MG cell lysate, SiHa cell lysate, NCI-H226 cell lysate, NIH/3T3 cell lysate, mouse liver tissue, rat cerebellum tissue, SiHa.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:200 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 100 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes