DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10]

Catalog number HA722161

Price for HA722161

Size / count 100 µL

About this product

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Specifications

Catalog number: HA722161
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: DDIT4 antibody DDIT4_HUMAN antibody Dig2 antibody DNA damage inducible transcript 4 antibody DNA damage inducible transcript 4 protein antibody DNA damage-inducible transcript 4 protein antibody FLJ20500 antibody HIF 1 responsive protein RTP801 antibody HIF 1 responsive RTP801 antibody HIF-1 responsive protein RTP801 antibody Protein regulated in development and DNA damage response 1 antibody REDD-1 antibody REDD1 antibody RTP801 antibody
Abbreviation: DDIT4
Swiss Prot: Q9NX09 Human
Cellular Locus: Mitochondrion, Cytoplasm, cytosol.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant full length protein.
Isotype: IgG
Clone: PS00-10
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HeLa treated with 0.5mM CoCl2 for 6 hours cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 25 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10]?

The catalog number for DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] is HA722161.

What sizes are available for DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10]?

DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] is available in the following size(s): 100 µL.

Is DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] in stock?

DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.