cIAP1 Recombinant Rabbit Monoclonal Antibody [PSH02-10]

About this product

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Specifications

Catalog number

HA721769

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

API 1 antibody API1 antibody Apoptosis inhibitor 1 antibody Baculoviral IAP repeat containing 2 antibody Baculoviral IAP repeat containing protein 2 antibody Baculoviral IAP repeat-containing protein 2 antibody BIRC 2 antibody BIRC2 antibody BIRC2_HUMAN antibody C IAP1 antibody C-IAP1 antibody Cellular inhibitor of apoptosis 1 antibody cellular inhibitor of apoptosis protein 1 antibody cIAP 1 antibody cIAP1 antibody HIAP 2 antibody HIAP-2 antibody HIAP2 antibody IAP 2 antibody IAP homolog B antibody IAP-2 antibody IAP2 antibody Inhibitor of apoptosis protein 2 antibody MIHB antibody NFR2 TRAF signalling complex protein antibody RING finger protein 48 antibody RNF 48 antibody RNF48 antibody TNFR2 TRAF signaling complex protein 2 antibody TNFR2-TRAF-signaling complex protein 2 antibody

Abbreviation

BIRC2, API1, MIHB, RNF48

Swiss Prot

Q13490 Human

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human cIAP1 aa 201-618 / 618.

Isotype

IgG

Clone

PSH02-10

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HT-29 cell lysate, TF-1 cell lysate, HepG2 cell lysate, HeLa cell lysate, THP-1 cell lysate, Jurkat cell lysate, A549 cell lysate, HEK-293 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes