RTN3 Recombinant Rabbit Monoclonal Antibody [PSH0-40]

About this product

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

Specifications

Catalog number

HA721342

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ASYIP antibody Neuroendocrine specific protein like 2 antibody Neuroendocrine-specific protein-like 2 antibody Neuroendocrine-specific protein-like II antibody NSP like protein II antibody NSP-like protein 2 antibody NSP-like protein II antibody NSPL2 antibody NSPLII antibody Reticulon 3 antibody Reticulon-3 antibody Reticulon3 antibody Rtn3 antibody RTN3_HUMAN antibody

Abbreviation

RTN3, ASYIP, NSPL2

Swiss Prot

O95197 Human, Q6RJR6 Rat

Cellular Locus

Endoplasmic reticulum membrane, Golgi apparatus membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within human RTN3 aa 1-500 / 1,032.

Isotype

IgG

Clone

PSH0-40

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

HeLa cell lysate, HEK-293 cell lysate, U87-MG cell lysate, A549 cell lysate, SH-SY5Y cell lysate, PC-12 cell lysate, L6 cell lysate, human cerebellum tissue lysate, PC-12, HeLa.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 112.6 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes