HDAC5 Recombinant Rabbit Monoclonal Antibody [PSH08-70]

About this product

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

Catalog number

HA723022

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antigen NY CO 9 antibody Antigen NY-CO-9 antibody HD5 antibody HDAC 5 antibody HDAC5 antibody HDAC5_HUMAN antibody Histone deacetylase 5 antibody NY CO 9 antibody

Abbreviation

Histone deacetylase 5, HD5, Antigen NY-CO-9, HDAC5, KIAA0600

Swiss Prot

Q9UQL6 Human, Q9Z2V6 Mouse,

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human HDAC5 aa 171-220.

Isotype

IgG

Clone

PSH08-70

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P, IF-Cell, IP, ChIP

Positive Control

Human stomach tissue, mouse stomach tissue, rat stomach tissue, HepG2, NIH/3T3, C6.

Concentration

1 mg/mL

Dilution

IHC-P: 1:1,000 ;IF-Cell: 1:100 ;IP: 1-2μg/sample ;ChIP: Use 0.5~2 μg for 25 μg of chromatin.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 122 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes