Notch2 Recombinant Rabbit Monoclonal Antibody [PSH0-55]

About this product

Neurogenic locus notch homolog protein 2 (Notch 2) is a protein that in humans is encoded by the NOTCH2 gene. NOTCH2 is associated with Alagille syndrome[6] and Hajdu–Cheney syndrome. Notch 2 is a member of the notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Mutations within the last coding exon of Notch2 that remove the PEST domain and escape the nonsense-mediated mRNA decay have been shown to be the main cause of the Hajdu-Cheney syndrome.

Specifications

Catalog number

HA721402

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AGS2 antibody hN2 antibody Motch B antibody N2 antibody N2ECD antibody N2ICD antibody neurogenic locus notch homolog protein 2 antibody NOTC2_HUMAN antibody Notch 2 antibody Notch 2 intracellular domain antibody Notch Drosophila homolog 2 antibody Notch homolog 2 antibody Notch homolog 2 Drosophila antibody Notch2 antibody

Abbreviation

NOTCH2

Swiss Prot

Q04721 Human

Cellular Locus

Cell membrane, Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human Notch2 aa 2,151-2,350/2,471.

Isotype

IgG

Clone

PSH0-55

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

293T cell lysate, HepG2 cell lysate, PC-3M cell lysate, U-87 MG cell lysate, HCT116 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 265 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes