TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58]

Catalog number HA721959

Price for HA721959

Size / count 100 µL

About this product

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor). TRPM8 is an ion channel: upon activation, it allows the entry of Na+ and Ca2+ ions into the cell, which leads to depolarization and the generation of an action potential. The signal is conducted from primary afferents (type C- and A-delta) eventually leading to the sensation of cold and cold pain. The TRPM8 protein is expressed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as menthol and icilin whereas WS-12 and CPS-369 are the most selective agonists of TRPM8. TRPM8 is also expressed in the prostate, lungs, and bladder where its function is not well understood.

Specifications

Catalog number: HA721959
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Long transient receptor potential channel 6 antibody LTrpC-6 antibody LTrpC6 antibody MGC2849 antibody Short form of the TRPM8 cationic channel antibody Transient receptor potential cation channel subfamily M member 8 antibody Transient receptor potential p8 antibody transient receptor potential-p8 antibody Trp p8 antibody Trp-p8 antibody Trpm8 antibody TRPM8_HUMAN antibody TRPP8 antibody
Abbreviation: TRPM8, LTRPC6, TRPP8
Swiss Prot: Q7Z2W7 Human
Cellular Locus: Cell membrane, Membrane raft, Endoplasmic reticulum membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human TRPM8 aa 851-1,050 / 1,104.
Isotype: IgG
Clone: JE32-58
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: LNCaP cell lysate, MCF7 cell lysate, HCT 116 cell lysate, human liver cancer tissue, human prostate cancer tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 128 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58]?

The catalog number for TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58] is HA721959.

What sizes are available for TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58]?

TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58] is available in the following size(s): 100 µL.

Is TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58] in stock?

TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58] is currently made to order / not held in immediate stock. Contact us for lead time.

What is TRPM8 Recombinant Rabbit Monoclonal Antibody [JE32-58] used for?

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.