Recombinant Mouse Interleukin-2/IL-2 Protein (active)

Specifications

Catalog number

PKSM041523-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes.

Abbreviation

Interleukin-2/IL-2

Synonyms

Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin

UniProt

P04351

Accession Number

P04351

Expression System

HEK293 cells

Tag

C-His

Sequence

Ala21-Gln169

Field of Research

Immunology

Endotoxin

≤0.1 EU per μg by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 0.88-3.5 ng/mL, corresponding to a specific activity of 2.86x105-1.14x106 units/mg.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.07 kDa

Observed Molecular Weight

22-25 kDa

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Species

Mouse