CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70]

Catalog number HA721458

Price for HA721458

Size / count 100 µL

About this product

Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans. Cereblon forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1). This complex ubiquitinates a number of other proteins. Through a mechanism which has not been completely elucidated, this ubiquitination results in reduced levels of fibroblast growth factor 8 (FGF8) and fibroblast growth factor 10 (FGF10). FGF8 in turn regulates a number of developmental processes, such as limb and auditory vesicle formation. The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos. In the absence of cereblon, DDB1 forms a complex with DDB2 that functions as a DNA damage-binding protein. Furthermore, cereblon and DDB2 bind to DDB1 in a competitive manner.

Specifications

Catalog number: HA721458
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 2610203G15Rik antibody 2900045O07Rik antibody AF229032 antibody AW108261 antibody Cereblon antibody Crbn antibody CRBN_HUMAN antibody DKFZp781K0715 antibody MGC27358 antibody MRT2A antibody OTTHUMP00000209555 antibody piL antibody Protein cereblon antibody Protein x 0001 antibody
Abbreviation: CRBN
Swiss Prot: Q96SW2 Human, Q8C7D2 Mouse, Q56AP7 Rat
Cellular Locus: Cytoplasm, Nucleus, Membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human CRBN aa 1-442 / 442.
Isotype: IgG
Clone: PSH0-70
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: HEK-293 cell lysate, A375 cell lysate, A549 cell lysate, HeLa cell lysate, SH-SY5Y cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, rat testis tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 51 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70]?

The catalog number for CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70] is HA721458.

What sizes are available for CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70]?

CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70] is available in the following size(s): 100 µL.

Is CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70] in stock?

CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70] is currently made to order / not held in immediate stock. Contact us for lead time.

What is CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-70] used for?

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.