Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90]

Catalog number HA721525

Price for HA721525

Size / count 100 µL

About this product

Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack and Bric-à-Brac (BTB) domain contains the Cys151 residue, which is one of the important cysteines in stress sensing. The intervening region (IVR) domain contains two critical cysteine residues, Cys273 and Cys288, which are a second group of cysteines important for stress sensing. A double glycine repeat (DGR) and C-terminal region (CTR) domains collaborate to form a β-propeller structure, which is where Keap1 interacts with Nrf2. Mutations in KEAP1 that result in loss-of-function are not linked to familial cancers, though they do predispose individuals to multinodular goiters. The proposed mechanism leading to goiter formation is that the redox stress experienced when the thyroid produces hormones selects for loss of heterozygosity of KEAP1, leading to the goiters.

Specifications

Catalog number: HA721525
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Cytosolic inhibitor of Nrf2 antibody INrf 2 antibody INrf2 antibody Keap 1 antibody KEAP1 antibody KEAP1_HUMAN antibody Kelch like ECH associated protein 1 antibody Kelch like family member 19 antibody Kelch like protein 19 antibody Kelch-like ECH-associated protein 1 antibody Kelch-like protein 19 antibody KIAA0132 antibody KLHL 19 antibody KLHL19 antibody MGC10630 antibody MGC1114 antibody MGC20887 antibody MGC4407 antibody MGC9454 antibody
Abbreviation: KEAP1, INRF2, KIAA0132, KLHL19
Swiss Prot: Q14145 Human, Q9Z2X8 Mouse, P57790 Rat
Cellular Locus: Cytoplasm, Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human Keap1 aa 275-624 / 624.
Isotype: IgG
Clone: PSH0-90
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: HepG2 cell lysate, HeLa cell lysate, MCF7 cell lysate, A431 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, Daudi cell lysate, A549 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse kidney tissue, rat kidney tissue, PC-12.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:1,000 ;FC: 1:500-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 70 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90]?

The catalog number for Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90] is HA721525.

What sizes are available for Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90]?

Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90] is available in the following size(s): 100 µL.

Is Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90] in stock?

Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Keap1 Recombinant Rabbit Monoclonal Antibody [PSH0-90] used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.