Elab Fluor® 488 Anti-Human CD192/CCR2 Antibody[K036C2]

Specifications

Catalog number

E-AB-F1385L-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4) . Two spliced variants were initially described for CCR2 (CCR2A and CCR2B) . These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.

Abbreviation

CD192

Gene ID

729230

UniProt

P41597

Host

Mouse

Reactivity

Human

Target

CC-CKR-2; CCR2A; CCR2B; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R

Clonality

Monoclonal

Clone

K036C2

Conjugation

Elab Fluor®488

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Innate Immunity; Neuroinflammation; Neuroscience

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG2a, κ