VEGF-R2 / CD309 / Flk-1 / KDR3 (DC101), CF594 conjugate, 0.1mg/mL

About this product

This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC940531-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CD309; Fetal liver kinase 1 (FLK-1) ; KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase) ; KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Vascular endothelial growth factor receptor 2

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

Kdr (Mouse)

Gene ID

16542

NCBI Gene ID

285

UniProt

35918

Swiss Prot

35918

Host

Rat

Species Reactivity

Mouse

Reactivity

CD309|Flk-1|KDR3|VEGF-R2

Immunogen

Recombinant full-length Mouse VEGFR2 protein

Target Antigen

CD309 | Flk-1 | KDR3 | VEGF-R2

Clonality

Monoclonal

Clone

DC101

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published) |IHC, frozen (published)

Positive Control

Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

180-190 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Cancer Metastasis Rev (1998) 17(2):155-61. (functional studies) J Exp Med (2001) 193(9): 1005-1014. (Flow) FASEB J (2005) 19(14): 2005-2007. (IHC, frozen)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF594