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Product details
Catalog number BNUB1032-500
Price for BNUB1032-500
Size / count 1x 500 µL
The wild-type anaplastic lymphoma kinase (ALK) protein is a 200 kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes) . ALK has been found to be rearranged, mutated, or amplified in a series of tumors. The hybrid gene, NPM-ALK, created by the t (2;5) (p23; q35) chromosomal translocation, encodes part of the nucleolar phosphoprotein nucleophosmin (NPM), joined to the entire cytoplasmic portion of ALK. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80 kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL) . Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein, producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is BNUB1032-500.
ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is available in the following size(s): 1x 500 µL.
ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is manufactured by Biotium.
Estimated delivery time for ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for ALK (Anaplastic Lymphoma Kinase) / CD246 (ALK/1032), 0.2mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
The wild-type anaplastic lymphoma kinase (ALK) protein is a 200 kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes) . ALK has been found to be rearranged, mut
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
