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Product details
Catalog number BNUM1294-50
Price for BNUM1294-50
Size / count 1x 50 µL
Recognizes a disaccharide epitope, Gal 1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF , including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The TF antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. Considered to be a pan-carcinoma marker. It is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. It is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. TF antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. Its presence on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide. This antibody is available purified, with BSA, or purified, BSA- and azide-free.
The catalog number for Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is BNUM1294-50.
Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is available in the following size(s): 1x 50 µL.
Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is manufactured by Biotium.
Estimated delivery time for Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) (A84-A/F10), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
Recognizes a disaccharide epitope, Gal 1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF , including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The TF antigen acts as an oncofet
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