Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL

Catalog number BNC401471-500

Price for BNC401471-500

Size / count 1x 500 µL

About this product

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1, 3, 5, 6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR) . In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC401471-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD51; DKFZp686A08142; integrin alpha V beta 3; Integrin alpha-5 Integrin alpha-V light chain; integrin alphaVbeta3; integrin; alpha V (vitronectin receptor; alpha polypeptide; antigen CD51) ; ITGAV; Msk8; VNRA; VTNR
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ITGAV
Gene ID: 3685
NCBI Gene ID: 436873
UniProt: P06756
Swiss Prot: P06756
Host: Mouse
Species Reactivity: Chicken, Human
Reactivity: CD51|CD61|Vitronectin Receptor
Immunogen: Osteoclasts from osteoclastomas
Target Antigen: CD51 | CD61 | Vitronectin Receptor
Clonality: Monoclonal
Clone: 23C6
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, surface (published) |Functional studies (published) |IF (published) |IHC, frozen (published) |IP (published) |WB (published)
Positive Control: Squamous cells, A375M melanoma cells. A549 cells.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 150-160 kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130 kDa 20-25 kDa.
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Cell Biol (1989) 109: 1817-1826. (IP, IF) Exp Cell Res (1991) 195:368-375. (IP, functional studies, IF) J Clin Invest (1992) 90: 1513-1522. (functional studies). Am J Pathol (1997) 150(4): 1383-1393. (IHC, frozen) Br J Cancer (1998) 77(4): 530-536. (Flow)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL?

The catalog number for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is BNC401471-500.

What sizes are available for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL?

Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL in stock?

Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL?

Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Vitronectin Receptor / CD51 / CD61 (23C6), CF640R conjugate, 0.1mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.