Vitronectin Receptor / CD51 / CD61 (23C6), 1mg/mL

About this product

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1, 3, 5, 6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR) . In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1471-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CD51; DKFZp686A08142; integrin alpha V beta 3; Integrin alpha-5 Integrin alpha-V light chain; integrin alphaVbeta3; integrin; alpha V (vitronectin receptor; alpha polypeptide; antigen CD51) ; ITGAV; Msk8; VNRA; VTNR

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

ITGAV

Gene ID

3685

NCBI Gene ID

436873

UniProt

P06756

Swiss Prot

P06756

Host

Mouse

Species Reactivity

Chicken, Human

Reactivity

CD51|CD61|Vitronectin Receptor

Immunogen

Osteoclasts from osteoclastomas

Target Antigen

CD51 | CD61 | Vitronectin Receptor

Clonality

Monoclonal

Clone

23C6

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published) |IF (published) |IHC, frozen (published) |IP (published) |WB (published)

Positive Control

Squamous cells, A375M melanoma cells. A549 cells.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

150-160 kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130 kDa 20-25 kDa.

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Cell Biol (1989) 109: 1817-1826. (IP, IF) Exp Cell Res (1991) 195:368-375. (IP, functional studies, IF) J Clin Invest (1992) 90: 1513-1522. (functional studies). Am J Pathol (1997) 150(4): 1383-1393. (IHC, frozen) Br J Cancer (1998) 77(4): 530-536. (Flow)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free