CD137L / 4-1BBL / TNFSF9 (CD137L/1547), 1mg/mL

About this product

TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1547-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

4-1BB ligand; 4-1BBL; CD137L; ILA ligand (TNF related) ; Ly63l; Tumor necrosis factor ligand 5A (TNLG5A) ; Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TNFSF9

Gene ID

8744

NCBI Gene ID

1524

UniProt

P41273

Swiss Prot

P41273

Host

Mouse

Species Reactivity

Human

Reactivity

4-1BBL|CD137L|TNFSF9

Immunogen

Recombinant full-length human CD137L protein

Target Antigen

4-1BBL | CD137L | TNFSF9

Clonality

Monoclonal

Clone

CD137L/1547

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |IHC, FFPE (verified)

Positive Control

Raji, 293T, HEK293 cells. Kidney.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

27 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free