Angiotensin I Converting Enzyme (ACE) / CD143 (9B9), 1mg/mL

About this product

Angiotensin-converting enzyme (ACE), also known as CD143, encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1560-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Angiotensin 1 converting enzyme; angiotensin-converting enzyme; ACE; carboxycathepsin; CD143; dipeptidyl carboxypeptidase 1; Kininase II; peptidase P

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

ACE

Gene ID

1636

NCBI Gene ID

298469

UniProt

P12821

Swiss Prot

P12821

Host

Mouse

Species Reactivity

Human

Reactivity

Angiotensin I Converting Enzyme|CD143

Immunogen

Full-length recombinant human ACE/CD143 protein

Target Antigen

Angiotensin I Converting Enzyme | CD143

Clonality

Monoclonal

Clone

9B9

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (verified)

Positive Control

Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

195 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free