Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL

Catalog number BNUM1563-50

Price for BNUM1563-50

Size / count 1x 50 µL

About this product

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUM1563-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: FLG
Gene ID: 2312
NCBI Gene ID: 654510
UniProt: P20930
Swiss Prot: P20930
Host: Mouse
Species Reactivity: Human
Reactivity: Filaggrin
Immunogen: Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary)
Target Antigen: Filaggrin
Clonality: Monoclonal
Clone: FLG/1563
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cell adhesion
Positive Control: U-251-MG cells. Skin.
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 26-45 kDa (Processed) ; 350 kDa (Profilaggrin)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL?

The catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is BNUM1563-50.

What sizes are available for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is available in the following size(s): 1x 50 µL.

Is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL in stock?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL?

Estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL?

The safety data sheet for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1563), 1mg/mL used for?

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.