Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL

Catalog number BNC471592-100

Price for BNC471592-100

Size / count 1x 100 µL

About this product

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B) . Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC471592-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Aurora kinase B; Aurora B; Aurora-1; AURKB; AIK2; AIM-1; ARK-2; AurB; Aurora and Ipl1 like midbody associated protein 1; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: AURKB
Gene ID: 9212
NCBI Gene ID: 442658
UniProt: Q96GD4
Swiss Prot: Q96GD4
Host: Mouse
Species Reactivity: Human
Reactivity: Aurora kinase B
Immunogen: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
Target Antigen: Aurora kinase B
Clonality: Monoclonal
Clone: AURKB/1592
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 39 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL?

The catalog number for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is BNC471592-100.

What sizes are available for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL in stock?

Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL?

The safety data sheet for Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b5061270361e10af19/msds/bnc471592-100.pdf.

What is Aurora B (Proliferation Marker) (AURKB/1592), CF647 conjugate, 0.1mg/mL used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.