Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL

Catalog number BNC941592-500

Price for BNC941592-500

Size / count 1x 500 µL

About this product

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B) . Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC941592-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Aurora kinase B; Aurora B; Aurora-1; AURKB; AIK2; AIM-1; ARK-2; AurB; Aurora and Ipl1 like midbody associated protein 1; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: AURKB
Gene ID: 9212
NCBI Gene ID: 442658
UniProt: Q96GD4
Swiss Prot: Q96GD4
Host: Mouse
Species Reactivity: Human
Reactivity: Aurora kinase B
Immunogen: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
Target Antigen: Aurora kinase B
Clonality: Monoclonal
Clone: AURKB/1592
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 39 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL?

The catalog number for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is BNC941592-500.

What sizes are available for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL in stock?

Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL?

The safety data sheet for Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Aurora B (Proliferation Marker) (AURKB/1592), CF594 conjugate, 0.1mg/mL used for?

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.