Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL

Catalog number BNUM1593-50

Price for BNUM1593-50

Size / count 1x 50 µL

About this product

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B) . Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUM1593-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Aurora kinase B; Aurora B; Aurora-1; AURKB; AIK2; AIM-1; ARK-2; AurB; Aurora and Ipl1 like midbody associated protein 1; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: AURKB
Gene ID: 9212
NCBI Gene ID: 442658
UniProt: Q96GD4
Swiss Prot: Q96GD4
Host: Mouse
Species Reactivity: Human
Reactivity: Aurora kinase B
Immunogen: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
Target Antigen: Aurora kinase B
Clonality: Monoclonal
Clone: AURKB/1593
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Cell cycle
Positive Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 39 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL?

The catalog number for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is BNUM1593-50.

What sizes are available for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is available in the following size(s): 1x 50 µL.

Is Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL in stock?

Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL?

Estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL?

The safety data sheet for Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Aurora B (Proliferation Marker) (AURKB/1593), 1mg/mL used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.