Endoglin / CD105 (ENG/1621), CF594 conjugate, 0.1mg/mL

About this product

CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for prostate adenocarcinoma, and cancers of the lung, stomach, breast, and brain. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC941621-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CD105; END; Endoglin; Eng; HHT1; S-endoglin

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

ENG

Gene ID

2022

NCBI Gene ID

76753

UniProt

P17813

Swiss Prot

P17813

Host

Mouse

Species Reactivity

Horse, Human, Monkey, Pig, Rat

Reactivity

CD105|Endoglin

Immunogen

Recombinant extracellular fragment of human Endoglin protein (exact sequence is proprietary)

Target Antigen

CD105 | Endoglin

Clonality

Monoclonal

Clone

ENG/1621

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |IF (verified)

Field of Research

Cancer

Positive Control

HeLa, A431 and HL-60 cells. Colon.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

84 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF594