CD79a (B-Cell Marker) (ZL7-4), 1mg/mL

About this product

A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20) . This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1627-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

B lymphocyte-specific MB1 protein; B-cell antigen receptor complex-associated protein alpha chain; CD79a molecule immunoglobulin associated alpha; Ig-alpha; IGA; IgM-alpha; Immunoglobulin-associated alpha; Ly54; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD79A

Gene ID

973

NCBI Gene ID

631567

UniProt

P11912

Swiss Prot

P11912

Host

Mouse

Species Reactivity

Human

Reactivity

CD79a

Immunogen

IgM complex isolated from Daudi cells.

Target Antigen

CD79a

Clonality

Monoclonal

Clone

ZL7-4

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |Flow, surface (published) |Functional studies (published) |IHC, FFPE (published) |IF (verified) |IP (published)

Positive Control

Raji, Daudi, Ramos cells. Germinal center B- cells in a lymph node or tonsil.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

44 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Cytometry Pt A (1999) 38:102-105. (Flow, surface) Blood (2002) 100(9): 3068-3076. (Flow, surface) Blood (2003) 101(3): 1087-1093. (functional studies) PLoS One (2013) 8(10): e76115. (IHC, FFPE) Nat Comm (2017) 8: 246. (functional studies; IP)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free