CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL — image 1 of 2

Product details

CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL

Catalog number BNCB1628-500

Price for BNCB1628-500

Size / count 1x 500 µL

About this product

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) . A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. This MAb binds to the CD8 alpha chain, at an epitope distinct from that recognized by UCHT14. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB1628-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD8 antigen; alpha polypeptide (p32) ; T8/Leu-2 T-lymphocyte differentiation antigen; Ly3; LYT3; MAL; T-cell surface glycoprotein CD8 alpha chain
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD8A
Gene ID: 925
NCBI Gene ID: 85258
UniProt: P01732
Swiss Prot: P01732
Host: Mouse
Species Reactivity: Human
Reactivity: CD8A
Immunogen: Thymocytes followed by Sezary T cells.
Target Antigen: CD8A
Clonality: Monoclonal
Clone: UCHT4
Type: Primary
Source: Animal
Origin: Animal
Applications: Functional studies (published) |IF (published) |Flow, surface (verified) |IP (published)
Positive Control: Jurkat, HuT78 or hPBL. Tonsil.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 32 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Immunol (2005) 35: 2896-2908. (functional studies) J Biol Chem (2007) 282(18): 13884-13894. (immunoprecipitation) Traffic (2015) 16(12): 1330-1341. (immunofluorescence)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL?

The catalog number for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is BNCB1628-500.

What sizes are available for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL?

CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL in stock?

CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL?

CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL?

The safety data sheet for CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CD8A (Cytotoxic- & Suppressor T-Cell Marker) (UCHT4), Biotin conjugate, 0.1mg/mL used for?

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.