CD44v6 (Marker of Tumor Metastasis) (2F10), 0.2mg/mL

About this product

This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB1629-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

LHR; BA-1; chondroitin sulfate proteoglycan 8 (CSPG8) ; Epican; Extracellular Matrix Receptor III (ECM III) ; GP90 Lymphocyte Homing Adhesion Receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan Sulfate Proteoglycan; Hermes Antigen; HAS; HUTCH I; Hyaluronate Receptor; Indian blood group; Inlu Related p80 Glycoprotein; Ly 24; MDU2; MDU3; MIC4; MUTCH I; Phagocytic Glycoprotein 1 (PGP-1)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD44

Gene ID

960

NCBI Gene ID

502328

UniProt

P16070

Swiss Prot

P16070

Host

Mouse

Species Reactivity

Human

Reactivity

CD44v6

Immunogen

Recombinant human CD44v3-10 Protein

Target Antigen

CD44v6

Clonality

Monoclonal

Clone

2F10

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published) |IF (published) |IHC, FFPE (published) |IP (published) |WB (published)

Positive Control

Cervix or Tongue Squamous Cell Carcinoma

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

80-95 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Arthritis Rheumatism (2002) 46(8): 2059-2064. (IF; IP; WB; functional studies) J Inv Dermatol (2010) 130(7):1893-1903. (functional studies) Cancer Sci (2015) 106: 1421-1428. (IHC, FFPE; Flow)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA