TIMP1 (Marker of Lymph Node Metastasis) (2A5), CF405S conjugate, 0.1mg/mL

About this product

TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity) . PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC041648-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Collagenase inhibitor; EPO; Erythroid-Potentiating Activity (EPA) ; Fibroblast collagenase inhibitor; Human Collagenase Inhibitor (HCI) ; Metalloproteinase inhibitor 1; Tissue Inhibitor of Metalloproteinase 1 (TIMP1)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TIMP1

Gene ID

7076

NCBI Gene ID

522632

UniProt

P01033

Swiss Prot

P01033

Host

Mouse

Species Reactivity

Human

Reactivity

TIMP1

Immunogen

A synthetic peptide (aa 72-82) of human TIMP1 protein (FQALGDAADIR)

Target Antigen

TIMP1

Clonality

Monoclonal

Clone

2A5

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (published) |WB (published)

Positive Control

293 cells. Colon Carcinoma.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

23 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Gut (1998) 43:791-797. (WB; IHC, FFPE)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S