Cytokeratin 1 (Suprabasal Keratinocyte Marker) (LHK1), Biotin conjugate, 0.1mg/mL

About this product

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8) . Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10) . Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNCB1660-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

67kDa Cytokeratin; CK1; Cytokeratin-1; EHK1; Epidermolytic hyperkeratosis 1; EPPK; K1; Keratin Type II Cytoskeletal 1; Keratin-1; KRT1; KRT1A; NEPPK; Type II cytoskeletal 1; Type-II keratin Kb1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

KRT1

Gene ID

38748

NCBI Gene ID

80828

UniProt

P04264

Swiss Prot

P04264

Host

Mouse

Species Reactivity

Human, Rat

Reactivity

Cytokeratin 1

Immunogen

A 13-amino acid peptide (VRFVSTSYSGVTR) from the C-terminus of human KRT1 protein

Target Antigen

Cytokeratin 1

Clonality

Monoclonal

Clone

LHK1

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (verified)

Field of Research

Cancer, Cytoskeleton

Positive Control

Skin or Cervix.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

67 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

Biotin