Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL

Catalog number BNC401661-500

Price for BNC401661-500

Size / count 1x 500 µL

About this product

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC401661-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD220; HHF5; HINSR A; INSR; Insulin receptor; Insulin receptor subunit alpha; INSR
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: INSR
Gene ID: 3643
NCBI Gene ID: 465744
UniProt: P06213
Swiss Prot: P06213
Host: Mouse
Species Reactivity: Human
Reactivity: Insulin Receptor Alpha
Immunogen: Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)
Target Antigen: Insulin Receptor Alpha
Clonality: Monoclonal
Clone: INSR/1661
Type: Primary
Source: Animal
Origin: Animal
Positive Control: Jurkat cells. Human pancreas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 135 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL?

The catalog number for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is BNC401661-500.

What sizes are available for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL?

Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL in stock?

Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL?

Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029b061270361e101fe7/msds/bnc401661-500.pdf.

What is Insulin Receptor Alpha (INSR/1661), CF640R conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.