VEGF (Vascular Endothelial Growth Factor) (VG76e), 1mg/mL

About this product

This MAb recognizes proteins of 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF) . It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet-derived growth factor (PDGF) . There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1687-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

MVCD1; Vascular Endothelial Growth Factor A (VEGF-A) ; Vascular Permeability Factor (VPF) ; VEGFA

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

VEGFA

Gene ID

7422

NCBI Gene ID

73793

UniProt

P15692

Swiss Prot

P15692

Host

Mouse

Species Reactivity

Human

Reactivity

VEGF

Immunogen

Human VEGF189 recombinant protein

Target Antigen

VEGF

Clonality

Monoclonal

Clone

VG76e

Type

Primary

Source

Animal

Origin

Animal

Applications

Functional studies (published) |IHC, FFPE (published) |WB (published)

Positive Control

Tumor cells in astrocytomas, breast or ovarian carcinomas.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing)

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Endocrinology (2000) 141(3): 995-1000. (WB, functional studies) J Vet Diag Invest (2010) 22(1):105-108. (IHC, FFPE)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free