CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL

Catalog number BNC881696-100

Price for BNC881696-100

Size / count 1x 100 µL

About this product

CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC881696-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ALPS5; CD152; Celiac disease 3 (CELIAC3) ; Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) ; GRD4; GSE; ICOS; Insulin-dependent Diabetes Mellitus 12 (IDDM12)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CTLA4
Gene ID: 1493
NCBI Gene ID: 247824
UniProt: P16410
Swiss Prot: P16410
Host: Mouse
Species Reactivity: Cow, Human, Mouse, Rat
Reactivity: CD152|CTLA4
Immunogen: A synthetic peptide from CTLA4 (exact sequence is proprietary)
Target Antigen: CD152 | CTLA4
Clonality: Monoclonal
Clone: L4P2F5.F10
Type: Primary
Source: Animal
Origin: Animal
Positive Control: Jurkat or Raji cells. Lymph Node or Tonsil.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 30-43 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL?

The catalog number for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is BNC881696-100.

What sizes are available for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL?

CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL in stock?

CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL?

CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL?

The safety data sheet for CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF488A conjugate, 0.1mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.