CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), 1mg/mL

About this product

CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1696-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

ALPS5; CD152; Celiac disease 3 (CELIAC3) ; Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) ; GRD4; GSE; ICOS; Insulin-dependent Diabetes Mellitus 12 (IDDM12)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CTLA4

Gene ID

1493

NCBI Gene ID

247824

UniProt

P16410

Swiss Prot

P16410

Host

Mouse

Species Reactivity

Cow, Human, Mouse, Rat

Reactivity

CD152|CTLA4

Immunogen

A synthetic peptide from CTLA4 (exact sequence is proprietary)

Target Antigen

CD152 | CTLA4

Clonality

Monoclonal

Clone

L4P2F5.F10

Type

Primary

Source

Animal

Origin

Animal

Positive Control

Jurkat or Raji cells. Lymph Node or Tonsil.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

30-43 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free